Molecular Biology of Gastric Cancer

Grant number: 1087683 | Funding period: 2015 - 2016

Completed

Abstract

We will investigate whether there are particular patterns of DNA methylation in people who develop gastric cancer. This could provide a means of identifying people at high risk of developing the disease, which may assist with early detection. This would be expected to markedly improve survival. If we can identify lifestyle factors associated with gastric cancer methylation there may be opportunities for prevention of the disease.

Related publications (4)

Scholarly works icon

DNA methylation in peripheral blood and risk of gastric cancer: A prospective nested case-control study

JA Chamberlain, PA Dugué, JK Bassett, RL Milne, JE Joo, EM Wong, MT Brinkman, GW Stuart, A Boussioutas, MC Southey, GG Giles, H Mitchell, DR English, AM Hodge

2021-02-01

DNA methylation in peripheral blood is a potential biomarker of gastric cancer risk which could be used for early detection. We co..

Scholarly works icon

Stochastic epigenetic mutations are associated with risk of breast cancer, lung cancer, and mature b-cell neoplasms

A Gagliardi, PA Dugue, TH Nøst, MC Southey, DD Buchanan, DF Schmidt, E Makalic, AM Hodge, DR English, NW Doo, JL Hopper, G Severi, L Baglietto, A Naccarati, S Tarallo, L Pace, V Krogh, D Palli, S Panico, C Sacerdote

2020-10-01

Background: Age-related epigenetic dysregulations are associated with several diseases, including cancer. The number of stochastic..

Scholarly works icon

Dietary Intake of Nutrients Involved in One-Carbon Metabolism and Risk of Gastric Cancer: A Prospective Study

PA Dugué, JK Bassett, MT Brinkman, MC Southey, JE Joo, EM Wong, RL Milne, DR English, GG Giles, A Boussioutas, H Mitchell, AM Hodge

2019-05-19

Dietary intakes of B vitamins and other components involved in one-carbon metabolism, which is necessary for DNA replication, DNA ..

Scholarly works icon

DNA methylation-based biological aging and cancer risk and survival: Pooled analysis of seven prospective studies

PA Dugué, JK Bassett, JHE Joo, CH Jung, E Ming Wong, M Moreno-Betancur, D Schmidt, E Makalic, S Li, G Severi, AM Hodge, DD Buchanan, DR English, JL Hopper, MC Southey, GG Giles, RL Milne

2018-04-15

The association between aging and cancer is complex. Recent studies have developed measures of biological aging based on DNA methy..

University of Melbourne Researchers